Introducing the Enhanced Cervical Cancer Detection Model PapEMS-Net, Integrating EfficientNet, Multi-Verse Optimizer, and Softmax Entropy Classifier

Authors

  • M. Sandhya Vani Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Hyderabad-500075, Telangana, India
  • N. Rama Rao Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Hyderabad-500075, Telangana, India
Volume: 15 | Issue: 6 | Pages: 28986-28994 | December 2025 | https://doi.org/10.48084/etasr.12917

Abstract

Cervical cancer remains a leading cause of mortality in low-resource regions where early diagnosis is often delayed due to limited access to expert cytologists and manual screening methods. To address the need for a robust, automated diagnostic system, this study proposes PAP smear EfficientNet-MVO-Softmax classifier Network (PapEMS-Net), a deep learning-based architecture designed for accurate classification of cervical cell types in PAP smear images. This study introduces PapEMS-Net, a deep learning framework designed to classify cervical cells in PAP smear images. By combining EfficientNet, Multi-Verse Optimizer (MVO), and a Softmax Entropy Classifier, the model provides accurate and efficient classification. The proposed PapEMS-Net model, evaluated on the Single-cell PAP Smear Image Dataset for Medical Diagnosis (SIPaKMeD), achieved an accuracy of 99.43%, precision of 99.29%, recall of 99.37%, and F1-score of 99.31%, outperforming existing models. The visual analysis through confusion matrix, ROC curves, and predicted class distributions further validated the model’s discriminative capability across all five cytological classes.

Keywords:

cervical cancer, PAP smear, accuracy, optimization, deep learning, detection

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References

Z. Alyafeai and L. Ghouti, "A Fully-automated Deep Learning Pipeline for Cervical Cancer Classification," Expert Systems with Applications, vol. 141, Mar. 2020, Art. no. 112951. DOI: https://doi.org/10.1016/j.eswa.2019.112951

L. Zhe Wei, W. Azani Mustafa, M. Aminudin Jamlos, S. Zulkarnain Syed Idrus, and M. Hamzari Sahabudin, "Cervical Cancer Classification Using Image Processing Approach: A Review," IOP Conference Series: Materials Science and Engineering, vol. 917, no. 1, Sept. 2020, Art. no. 012068. DOI: https://doi.org/10.1088/1757-899X/917/1/012068

R. L. Siegel, K. D. Miller, N. S. Wagle, and A. Jemal, "Cancer Statistics, 2023," CA: A Cancer Journal for Clinicians, vol. 73, no. 1, pp. 17–48, Jan. 2023. DOI: https://doi.org/10.3322/caac.21763

M. S. Balkin, "Cervical Cancer Prevention and Treatment: Science, Public Health and Policy Overview," in Challenges and Opportunities for Women’s Right to Health, Brussels, Belgium, Sept. 2007.

T. Šarenac and M. Mikov, "Cervical Cancer, Different Treatments and Importance of Bile Acids as Therapeutic Agents in This Disease," Frontiers in Pharmacology, vol. 10, June 2019, Art. no. 484. DOI: https://doi.org/10.3389/fphar.2019.00484

H. Basak, R. Kundu, S. Chakraborty, and N. Das, "Cervical Cytology Classification Using PCA and GWO Enhanced Deep Features Selection," SN Computer Science, vol. 2, no. 5, Sept. 2021, Art. no. 369. DOI: https://doi.org/10.1007/s42979-021-00741-2

P. Oak, P. S. Deshpande, and B. Iyer, "A Deep Learning-Driven Multimodal Healthcare System for the Early Detection of Cervical Cancer," Engineering, Technology & Applied Science Research, vol. 15, no. 4, pp. 24328–24333, Aug. 2025. DOI: https://doi.org/10.48084/etasr.11277

S. L. Bedell, L. S. Goldstein, A. R. Goldstein, and A. T. Goldstein, "Cervical Cancer Screening: Past, Present, and Future," Sexual Medicine Reviews, vol. 8, no. 1, pp. 28–37, Jan. 2020. DOI: https://doi.org/10.1016/j.sxmr.2019.09.005

N. Dong, L. Zhao, C. H. Wu, and J. F. Chang, "Inception v3 Based Cervical Cell Classification Combined with Artificially Extracted Features," Applied Soft Computing, vol. 93, Aug. 2020, Art. no. 106311. DOI: https://doi.org/10.1016/j.asoc.2020.106311

U. E. Akpudo and J.-W. Hur, "D-dCNN: A Novel Hybrid Deep Learning-Based Tool for Vibration-Based Diagnostics," Energies, vol. 14, no. 17, Aug. 2021, Art. no. 5286. DOI: https://doi.org/10.3390/en14175286

K. P. Win, Y. Kitjaidure, K. Hamamoto, and T. Myo Aung, "Computer-Assisted Screening for Cervical Cancer Using Digital Image Processing of Pap Smear Images," Applied Sciences, vol. 10, no. 5, Mar. 2020, Art. no. 1800. DOI: https://doi.org/10.3390/app10051800

T. Zhang et al., "Cervical Precancerous Lesions Classification Using Pre-trained Densely Connected Convolutional Networks with Colposcopy Images," Biomedical Signal Processing and Control, vol. 55, Jan. 2020, Art. no. 101566. DOI: https://doi.org/10.1016/j.bspc.2019.101566

W. Hua et al., "Lymph-vascular Space Invasion Prediction in Cervical Cancer: Exploring Radiomics and Deep Learning Multilevel Features of Tumor and Peritumor Tissue on Multiparametric MRI," Biomedical Signal Processing and Control, vol. 58, Apr. 2020, Art. no. 101869. DOI: https://doi.org/10.1016/j.bspc.2020.101869

A. Khamparia, D. Gupta, J. J. P. C. Rodrigues, and V. H. C. De Albuquerque, "DCAVN: Cervical Cancer Prediction and Classification Using Deep Convolutional and Variational Autoencoder Network," Multimedia Tools and Applications, vol. 80, no. 20, pp. 30399–30415, Aug. 2021. DOI: https://doi.org/10.1007/s11042-020-09607-w

T. I. Yusufaly et al., "A Knowledge-based Organ Dose Prediction Tool for Brachytherapy Treatment Planning of Patients with Cervical Cancer," Brachytherapy, vol. 19, no. 5, pp. 624–634, Sept. 2020. DOI: https://doi.org/10.1016/j.brachy.2020.04.008

S. I. Kim, S. Lee, C. H. Choi, M. Lee, J. W. Kim, and Y. B. Kim, "Prediction of Disease Recurrence According to Surgical Approach of Primary Radical Hysterectomy in Patients with Early-stage Cervical Cancer Using Machine Learning Methods," Gynecologic Oncology, vol. 159, pp. 185–186, Oct. 2020. DOI: https://doi.org/10.1016/j.ygyno.2020.05.283

M. Suriya, V. Chandran, and M. G. Sumithra, "Enhanced Deep Convolutional Neural Network for Malarial Parasite Classification," International Journal of Computers and Applications, vol. 44, no. 12, pp. 1113–1122, Dec. 2022. DOI: https://doi.org/10.1080/1206212X.2019.1672277

T. A. Kessler, "Cervical Cancer: Prevention and Early Detection," Seminars in Oncology Nursing, vol. 33, no. 2, pp. 172–183, May 2017. DOI: https://doi.org/10.1016/j.soncn.2017.02.005

Y. R. Park, Y. J. Kim, W. Ju, K. Nam, S. Kim, and K. G. Kim, "Comparison of Machine and Deep Learning for the Classification of Cervical Cancer Based on Cervicography Images," Scientific Reports, vol. 11, no. 1, Aug. 2021, Art. no. 16143. DOI: https://doi.org/10.1038/s41598-021-95748-3

E. Hussain, L. B. Mahanta, C. R. Das, and R. K. Talukdar, "Comparison of Machine and Deep Learning for the Classification of Cervical Cancer Based on Cervicography Images," Tissue and Cell, vol. 65, Aug. 2020, Art. no. 101347. DOI: https://doi.org/10.1016/j.tice.2020.101347

M. E. Plissiti, M. Vrigkas, and C. Nikou, "Segmentation of Cell Clusters in Pap Smear Images Using Intensity Variation Between Superpixels," in 2015 International Conference on Systems, Signals and Image Processing, London, United Kingdom, Sept. 2015, pp. 184–187. DOI: https://doi.org/10.1109/IWSSIP.2015.7314207

N. Zamanitajeddin, M. Jahanifar, M. Bilal, M. Eastwood, and N. Rajpoot, "Social Network Analysis of Cell Networks Improves Deep Learning for Prediction of Molecular Pathways and Key Mutations in Colorectal Cancer," Medical Image Analysis, vol. 93, Apr. 2024, Art. no. 103071. DOI: https://doi.org/10.1016/j.media.2023.103071

A. K. Sharma, A. Nandal, A. Dhaka, A. Alhudhaif, K. Polat, and A. Sharma, "Diagnosis of Cervical Cancer Using CNN Deep Learning Model with Transfer Learning Approaches," Biomedical Signal Processing and Control, vol. 105, July 2025, Art. no. 107639. DOI: https://doi.org/10.1016/j.bspc.2025.107639

Y. Dogan, "AutoEffFusionNet: A New Approach for Cervical Cancer Diagnosis Using ResNet-Based Autoencoder with Attention Mechanism and Genetic Feature Selection," IEEE Access, vol. 13, pp. 44107–44122, 2025. DOI: https://doi.org/10.1109/ACCESS.2025.3543850

S. K. Mathivanan, D. Francis, S. Srinivasan, V. Khatavkar, K. P, and M. A. Shah, "Enhancing Cervical Cancer Detection and Robust Classification Through a Fusion of Deep Learning Models," Scientific Reports, vol. 14, no. 1, May 2024, Art. no. 10812. DOI: https://doi.org/10.1038/s41598-024-61063-w

Md. H. K. Mehedi, M. Khandaker, S. Ara, Md. A. Alam, M. F. Mridha, and Z. Aung, "A Lightweight Deep Learning Method to Identify Different Types of Cervical Cancer," Scientific Reports, vol. 14, no. 1, Nov. 2024, Art. no. 29446. DOI: https://doi.org/10.1038/s41598-024-79840-y

M. H. Sadananda, "Cervical Cancer Detection with a Tissue Smear and a Microscopic Image inside the Deep Learning Model of Squeeze Net," International Journal for Research in Applied Science and Engineering Technology, vol. 12, no. 5, pp. 4434–4437, May 2024. DOI: https://doi.org/10.22214/ijraset.2024.62579

N. M. Fahad, S. Azam, S. Montaha, and Md. S. H. Mukta, "Enhancing Cervical Cancer Diagnosis with Graph Convolution Network: Ai-powered Segmentation, Feature Analysis, and Classification for Early Detection," Multimedia Tools and Applications, vol. 83, no. 30, pp. 75343–75367, Feb. 2024. DOI: https://doi.org/10.1007/s11042-024-18608-y

B. Z. Wubineh, A. Rusiecki, and K. Halawa, "Classification of Cervical Cells from the Pap Smear Image Using the RES_DCGAN Data Augmentation and ResNet50V2 with Self-attention Architecture," Neural Computing and Applications, vol. 36, no. 34, pp. 21801–21815, Dec. 2024. DOI: https://doi.org/10.1007/s00521-024-10404-x

R. Pramanik, B. Banerjee, and R. Sarkar, "MSENet: Mean and Standard Deviation Based Ensemble Network for Cervical Cancer Detection," Engineering Applications of Artificial Intelligence, vol. 123, Aug. 2023, Art. no. 106336. DOI: https://doi.org/10.1016/j.engappai.2023.106336

M. E. Plissiti, P. Dimitrakopoulos, G. Sfikas, C. Nikou, O. Krikoni, and A. Charchanti, "Sipakmed: A New Dataset for Feature and Image Based Classification of Normal and Pathological Cervical Cells in Pap Smear Images," in 2018 25th IEEE International Conference on Image Processing, Athens, Oct. 2018, pp. 3144–3148. DOI: https://doi.org/10.1109/ICIP.2018.8451588

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How to Cite

[1]
M. S. Vani and N. R. Rao, “Introducing the Enhanced Cervical Cancer Detection Model PapEMS-Net, Integrating EfficientNet, Multi-Verse Optimizer, and Softmax Entropy Classifier”, Eng. Technol. Appl. Sci. Res., vol. 15, no. 6, pp. 28986–28994, Dec. 2025.

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