A Quantitative Analysis of Goblet Cells in the Rat Intestinal Using Imaging Techniques
Received: 25 May 2025 | Revised: 24 July 2025, 14 August 2025, and 19 August 2025 | Accepted: 20 August 2025 | Online: 7 December 2025
Corresponding author: A. M. M. Madbouly
Abstract
Goblet cells play a crucial role in maintaining intestinal health by secreting mucins, which form the protective mucus barrier in the gastrointestinal tract. These cells are essential for lubrication, immune defense, and protection against pathogens. The number and distribution of goblet cells are critical indicators of intestinal health, with abnormalities linked to various conditions such as the Inflammatory Bowel Disease (IBD). Accurate quantification of goblet cells is vital for diagnosing and monitoring these conditions. This paper presents an image-processing-based approach to automatically detect and count goblet cells within a defined region of interest. Using contrast enhancement, thresholding, and morphological analysis, our method provides a robust and efficient tool for goblet cell quantification. Experiments conducted on a private dataset of 61 histological images demonstrated high detection accuracy.
Keywords:
quantitative, image processing, goblet cells, morphological featuresDownloads
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Copyright (c) 2025 A. M. M. Madbouly, Mahmoud M. Abdelhamied, Shaimaa I. Mostafa
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