Deep Neural Networks for Precise Brain Tumor Delineation: A U-Net and TensorFlow Approach
Received: 22 February 2025 | Revised: 20 March 2025 and 7 April 2025 | Accepted: 12 April 2025 | Online: 4 May 2025
Corresponding author: H. R. Divakar
Abstract
Brain tumors, especially gliomas, are complex and aggressive growths of cells in the brain that lead to high morbidity and mortality. With high-grade gliomas having a median survival rate of under two years, accurate and timely diagnosis is crucial. Magnetic Resonance Imaging (MRI) is the primary method for detecting brain tumors, but manual interpretation by radiologists can be time-consuming and subject to variability. Therefore, there is a growing need for more reliable and automated methods. This study proposes a deep learning approach for Brain Tumor Segmentation (BraTS) using the U-Net model in TensorFlow. U-Net is well-suited for biomedical image segmentation due to its encoder-decoder structure and skip connections, which capture detailed information and spatial context. The model is trained on the BraTS 2020 dataset, which includes MRI scans of high-grade and low-grade gliomas across four sequences: Fluid-Attenuated Inversion Recovery (FLAIR), T1-weighted, T1-weighted with Contrast Enhancement (T1CE), and T2-weighted. This work demonstrates the potential of deep learning to improve medical imaging precision, enhancing diagnosis and treatment planning for brain tumor patients.
Keywords:
brain tumor segmentation, gliomas, deep learning, U-net architectureDownloads
References
V. P. B. Grover, J. M. Tognarelli, M. M. E. Crossey, I. J. Cox, S. D. Taylor-Robinson, and M. J. W. McPhail, "Magnetic Resonance Imaging: Principles and Techniques: Lessons for Clinicians," Journal of Clinical and Experimental Hepatology, vol. 5, no. 3, pp. 246–255, Sep. 2015.
N. Mo, L. Yan, R. Zhu, and H. Xie, "Class-Specific Anchor Based and Context-Guided Multi-Class Object Detection in High Resolution Remote Sensing Imagery with a Convolutional Neural Network," Remote Sensing, vol. 11, no. 3, Jan. 2019, Art. no. 272.
Perelman School of Medicine, University of Pennsylvania. BraTS 2020 Dataset.
S. Wang and Y. Zhang, "DenseNet-201-Based Deep Neural Network with Composite Learning Factor and Precomputation for Multiple Sclerosis Classification," ACM Transactions on Multimedia Computing, Communications, and Applications, vol. 16, no. 2s, pp. 1–19, Apr. 2020.
R. H. Mwawado, B. J. Maiseli, and M. A. Dida, "Robust Edge Detection Method for Segmentation of Diabetic Foot Ulcer Images," Engineering, Technology & Applied Science Research, vol. 10, no. 4, pp. 6034–6040, Aug. 2020.
S. Albawi, T. A. Mohammed, and S. Al-Zawi, "Understanding of a convolutional neural network," in 2017 International Conference on Engineering and Technology (ICET), Antalya, Aug. 2017, pp. 1–6.
N. C. Kundur, B. C. Anil, P. M. Dhulavvagol, R. Ganiger, and B. Ramadoss, "Pneumonia Detection in Chest X-Rays using Transfer Learning and TPUs," Engineering, Technology & Applied Science Research, vol. 13, no. 5, pp. 11878–11883, Oct. 2023.
P. Roy, S. Dutta, N. Dey, G. Dey, S. Chakraborty, and R. Ray, "Adaptive thresholding: A comparative study," in 2014 International Conference on Control, Instrumentation, Communication and Computational Technologies (ICCICCT), Kanyakumari District, India, Jul. 2014, pp. 1182–1186.
L. Maurya, V. Lohchab, P. Kumar Mahapatra, and J. Abonyi, "Contrast and brightness balance in image enhancement using Cuckoo Search-optimized image fusion," Journal of King Saud University - Computer and Information Sciences, vol. 34, no. 9, pp. 7247–7258, Oct. 2022.
G. Maragatham and S. Mansoor Roomi, "A Review of Image Contrast Enhancement Methods and Techniques," Research Journal of Applied Sciences, Engineering and Technology, vol. 9, no. 5, pp. 309–326, Feb. 2015.
A. Patel, "Benign vs Malignant Tumors," JAMA Oncology, vol. 6, no. 9, Sep. 2020, Art. no. 1488.
M. J. McAuliffe, F. M. Lalonde, D. McGarry, W. Gandler, K. Csaky, and B. L. Trus, "Medical Image Processing, Analysis and Visualization in clinical research," in Proceedings 14th IEEE Symposium on Computer-Based Medical Systems. CBMS 2001, Bethesda, MD, USA, 2001, pp. 381–386.
W. Rawat and Z. Wang, "Deep Convolutional Neural Networks for Image Classification: A Comprehensive Review," Neural Computation, vol. 29, no. 9, pp. 2352–2449, Sep. 2017.
S. Thalagala and C. Walgampaya, "Application of AlexNet convolutional neural network architecture-based transfer learning for automated recognition of casting surface defects," in 2021 International Research Conference on Smart Computing and Systems Engineering (SCSE), Colombo, Sri Lanka, Sep. 2021, pp. 129–136.
O. Ronneberger, P. Fischer, and T. Brox, "U-Net: Convolutional Networks for Biomedical Image Segmentation." arXiv, 2015.
A. El Boustani, M. Aatila, E. El Bachari, and A. El Oirrak, "MRI Brain Images Classification Using Convolutional Neural Networks," in Advanced Intelligent Systems for Sustainable Development (AI2SD’2019), Cham, 2020, vol. 1105, pp. 308–320.
W. S. Salem, A. F. Seddik, and H. F. Ali, "A Review on Brain MRI Image Segmentation," in The Second International Conference on New Paradigms in Electronics and Information Technologies PEIT’013, Luxor, Egypt, Nov. 2013, vol. 1.
Y. Qi et al., "A Comprehensive Overview of Image Enhancement Techniques," Archives of Computational Methods in Engineering, vol. 29, no. 1, pp. 583–607, Jan. 2022.
J. Thirumaran and S. Shylaja, "Medical Image Processing-An Introduction," Computer Graphics and Image Processing, vol. 4, no. 11, pp. 1197–1199, Nov. 2014.
N. C. Kundur and P. B. Mallikarjuna, "Deep Convolutional Neural Network Architecture for Plant Seedling Classification," Engineering, Technology & Applied Science Research, vol. 12, no. 6, pp. 9464–9470, Dec. 2022.
B. H. Menze et al., "The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS)," IEEE Transactions on Medical Imaging, vol. 34, no. 10, pp. 1993–2024, Oct. 2015.
S. Bakas et al., "Advancing The Cancer Genome Atlas glioma MRI collections with expert segmentation labels and radiomic features," Scientific Data, vol. 4, no. 1, Sep. 2017, Art. no. 170117.
S. Bakas et al., "Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge." arXiv, Apr. 23, 2019.
M. Goyal, P. Rajpura, H. Bojinov, and R. Hegde, "Dataset Augmentation with Synthetic Images Improves Semantic Segmentation," in Computer Vision, Pattern Recognition, Image Processing, and Graphics, Singapore, 2018, vol. 841, pp. 348–359.
V. Badrinarayanan, A. Kendall, and R. Cipolla, "SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation," IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 39, no. 12, pp. 2481–2495, Dec. 2017.
F. Ketenci Çay, Ç. Yeşil, O. Çay, B. G. Yılmaz, F. H. Özçini, and D. İlgüy, "DeepLabv3 + method for detecting and segmenting apical lesions on panoramic radiography," Clinical Oral Investigations, vol. 29, no. 2, Jan. 2025, Art. no. 101.
O. Oktay et al., "Attention U-Net: Learning Where to Look for the Pancreas." arXiv, May 20, 2018.
D. Jha et al., "ResUNet++: An Advanced Architecture for Medical Image Segmentation." arXiv, 2019.
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Copyright (c) 2025 Niranjan C. Kundur, H. R. Divakar, Samitha Khaiyum, Kiran P. Rakshitha, Praveen M. Dhulavvagol, Anand S. Meti

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